Lukas S E
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02178, USA.
Annu Rev Pharmacol Toxicol. 1996;36:333-57. doi: 10.1146/annurev.pa.36.040196.002001.
Anabolic-androgenic steroids (AAS) have become more widely used and abused not only by elite athletes, but by nonathletes as well. It appears that these drugs are being used for cosmetic purposes as well as for promoting aggressive behavior. However, AASs may also be used in combination with other drugs such as ethyl alcohol and cocaine--a practice that may contribute to the observed increase in aggressive behavior. As there are no reliable animal models of AAS self-administration, it has been difficult to characterize the abuse liability and physical dependence potential of this class of drugs. A better understanding of neuroactive steroids, improved methods for assessing AAS abuse, and a revised interpretation of drug-seeking behavior is needed to develop improved treatment strategies for this emerging health-related problem.
合成代谢雄激素类固醇（AAS）不仅被精英运动员广泛使用和滥用，非运动员也如此。这些药物似乎不仅用于美容目的，还用于促进攻击性行为。然而，AAS也可能与其他药物如乙醇和可卡因联合使用——这种做法可能导致观察到的攻击性行为增加。由于没有可靠的AAS自我给药动物模型，很难确定这类药物的滥用倾向和身体依赖潜力。为了针对这个新出现的健康相关问题制定更好的治疗策略，需要更好地理解神经活性类固醇，改进评估AAS滥用的方法，以及对觅药行为进行修订解释。
