Scalori Astrid, Tavani Alessandra, Gallus Silvano, La Vecchia Carlo, Colombo Massimo
Divisione di Epatologia, Ospedale Maggiore IRCCS, Università degli Studi di Milano, Milan, Italy.
Am J Gastroenterol. 2002 Sep;97(9):2371-3. doi: 10.1111/j.1572-0241.2002.05796.x.
Risk factors for focal nodular hyperplasia (FNH) of the liver are largely unknown, except for a possible role of female hormones. We evaluated the role of tobacco smoking and some lifestyle and dietary factors in its etiology.
A hospital-based case-control study was conducted in Italy between January, 1999 and February, 2000 on 28 patients with histologically confirmed FNH of the liver and 115 controls in the hospital for acute, nonneoplastic, non-liver related diseases. Odds ratios (OR) and 95% confidence intervals (CI) were computed using multiple logistic regression equations.
Compared to those who never smoked the multivariate ORs were 1.9 (95% CI = 0.6-6.0) in ex-smokers and 3.5 (95% CI = 1.2-9.7) in current smokers, and the risk increased with number of cigarettes smoked to 8.0 (95% CI = 1.7-37.4) for > or = 20 cigarettes/day. Intake of whole-grain foods was inversely related to risk, with an OR of 0.3 (95% CI = 0.1-0.7) in consumers versus nonconsumers. No significant association was observed with education, alcohol drinking, and selected indicator foods.
This study indicates that cigarette smoking is an indicator of elevated risk for FNH of the liver, whereas whole grain and, possibly, vegetable intake seems to be a favorable indicator.
除了女性激素可能发挥的作用外，肝脏局灶性结节性增生（FNH）的危险因素大多未知。我们评估了吸烟以及一些生活方式和饮食因素在其病因学中的作用。
1999年1月至2000年2月在意大利开展了一项基于医院的病例对照研究，研究对象为28例经组织学确诊的肝脏FNH患者以及115例因急性、非肿瘤性、非肝脏相关疾病住院的对照者。使用多元逻辑回归方程计算比值比（OR）和95%置信区间（CI）。
与从不吸烟者相比，既往吸烟者的多变量OR为1.9（95%CI = 0.6 - 6.0），当前吸烟者的多变量OR为3.5（95%CI = 1.2 - 9.7），且风险随着吸烟量增加而升高，每日吸烟≥20支者的OR为8.0（95%CI = 1.7 - 37.4）。全谷物食品的摄入量与风险呈负相关，食用者与未食用者相比，OR为0.3（95%CI = 0.1 - 0.7）。未观察到教育程度、饮酒及所选指示性食物与之存在显著关联。
本研究表明，吸烟是肝脏FNH风险升高的一个指标，而全谷物以及可能的蔬菜摄入量似乎是一个有利指标。
