Ljunggren B
Contact Dermatitis. 1977 Apr;3(2):85-90. doi: 10.1111/j.1600-0536.1977.tb03604.x.
A case of acquired photocontact allergy to furocumarins in plants is reported. Photopatch testing was performed with four psoralens [8-methoxypsoralen (8-MOP), 5-methoxypsoralens (5-MOP), trimethylpsoralen (TMP) and imperatorin (IMP)[. The use of serial dilutions of the test compounds made it possible to differentiate between photoallergic and phototoxic reactions. 8-MOP gave a positive eczematous test reaction down to a concentration of 0.0001%. The reactions to 5-MOP and imp also were positive, while that to TMP awas negative. Histopathological examination of a biopsy specimen from a positive test site showed changes consistent with photoallergic contact dermatitis. The multiple reactions could be explained on the basis of multiple sensitization but cross reactions cannot be ruled out.
报告了一例对植物中呋喃香豆素的获得性光接触过敏病例。使用四种补骨脂素[8-甲氧基补骨脂素（8-MOP）、5-甲氧基补骨脂素（5-MOP）、三甲基补骨脂素（TMP）和欧前胡素（IMP）]进行光斑贴试验。使用受试化合物的系列稀释液能够区分光过敏反应和光毒性反应。8-MOP在浓度低至0.0001%时仍产生阳性湿疹试验反应。对5-MOP和IMP的反应也为阳性，而对TMP的反应为阴性。对阳性试验部位活检标本的组织病理学检查显示出与光过敏性接触性皮炎一致的变化。多种反应可基于多重致敏来解释，但交叉反应也不能排除。
