Sulkava R, Kainulainen K, Verkkoniemi A, Niinistö L, Sobel E, Davanipour Z, Polvikoski T, Haltia M, Kontula K
Department of Community Health and General Practice, University of Kuopio, Finland.
Neurobiol Aging. 1996 May-Jun;17(3):373-6. doi: 10.1016/0197-4580(96)00023-1.
Apolipoprotein E genotyping was carried out in a stratified random sample of 52 patients with Alzheimer's disease, 48 patients with vascular or mixed dementia, and 49 nondemented controls in a population-based study of people aged 85 and older (the Vantaa 85+ Study). Our results indicate that the apolipoprotein E epsilon 4 allele is associated with approximately a twofold increase in clinically diagnosed Alzheimer's disease in this very old general population aged 85+. When combined with previous studies, our data also suggest that the association is decreasing with age. In contrast, there appears to be no relation between apolipoprotein E alleles and clinically diagnosed vascular dementia.
在一项针对85岁及以上人群的基于人群的研究（万塔85+研究）中，对52例阿尔茨海默病患者、48例血管性或混合性痴呆患者以及49例非痴呆对照进行了载脂蛋白E基因分型。我们的结果表明，在这个85岁以上的非常年老的普通人群中，载脂蛋白Eε4等位基因与临床诊断的阿尔茨海默病增加约两倍有关。结合先前的研究，我们的数据还表明这种关联随着年龄的增长而减弱。相比之下，载脂蛋白E等位基因与临床诊断的血管性痴呆之间似乎没有关系。
