Treves T A, Bornstein N M, Chapman J, Klimovitzki S, Verchovsky R, Asherov A, Veshchev I O, Korczyn A D
Department of Neurology. Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Alzheimer Dis Assoc Disord. 1996 Winter;10(4):189-91. doi: 10.1097/00002093-199601040-00003.
The apolipoprotein E (APOE) epsilon 4 allele has been consistently found to be frequent in patients with progressive degenerative dementia of the Alzheimer type (DAT). Vascular dementia (VD) may occur as strokes superimposed on presymptomatic DAT, in which case APOE-epsilon 4 frequency should also be increased in VD. We have examined the distribution of APOE-epsilon 4 in patients with DAT (n = 176) or VD (n = 74) and controls (n = 133), and evaluated the risk of dementia associated with APOE-epsilon 4. APOE-epsilon 4 allele frequency was 27% in DAT patients, 21% in VD patients, and 11% in controls. The difference in the distribution of the epsilon 4 allele between DAT or VD patients and controls was statistically significant (chi(2) test, p < 0.05), with a 3.6- and 2.1-fold risk of dementia in DAT and VD patients carrying an epsilon 4 allele. The result that the APOE-epsilon 4 allele is more frequent in DAT patients than in controls, with VD patients falling in between, is consistent with the assumption that VD is a heterogeneous condition, with some patients having an underlying preclinical brain degeneration, in whom the dementia was precipitated by strokes.
载脂蛋白E（APOE）ε4等位基因一直被发现常见于阿尔茨海默病型（DAT）进行性退行性痴呆患者中。血管性痴呆（VD）可能作为叠加在症状前DAT上的中风而出现，在这种情况下，VD患者中APOE-ε4的频率也应增加。我们检查了DAT患者（n = 176）、VD患者（n = 74）和对照组（n = 133）中APOE-ε4的分布情况，并评估了与APOE-ε4相关的痴呆风险。DAT患者中APOE-ε4等位基因频率为27%，VD患者中为21%，对照组中为11%。DAT或VD患者与对照组之间ε4等位基因分布的差异具有统计学意义（卡方检验，p < 0.05），携带ε4等位基因的DAT和VD患者患痴呆的风险分别为3.6倍和2.1倍。APOE-ε4等位基因在DAT患者中比对照组更常见，VD患者的频率介于两者之间，这一结果与VD是一种异质性疾病的假设一致，即一些患者存在潜在的临床前脑退化，痴呆由中风引发。
