V(D)J 重组机制。
Mechanism of V(D)J recombination.
作者信息
Bogue M, Roth D B
机构信息
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Curr Opin Immunol. 1996 Apr;8(2):175-80. doi: 10.1016/s0952-7915(96)80055-0.
PMID:8725940
Abstract
V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved in both V(D)J recombination and double-strand break repair.
摘要
V(D)J重组可分为两个基本过程：DNA切割和断裂末端的连接。在过去的一年里，我们对这两个反应的理解有了显著提高。主要进展包括开发出一种能够进行切割的无细胞系统，以及鉴定出几种参与V(D)J重组和双链断裂修复的蛋白质。
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