Martínez M E, McPherson R S, Annegers J F, Levin B
University of Texas-Houston School of Public Health 77225, USA.
Epidemiology. 1996 May;7(3):264-8. doi: 10.1097/00001648-199605000-00008.
We conducted a case-control study to investigate the relation between dietary fiber, calcium, and total fat and the risk of colorectal adenomatous polyps. We used a food frequency questionnaire to assess the usual diet for 157 cases and 480 controls. In multivariate analyses, dietary fiber was inversely associated with risk of adenomatous polyps. The odds ratio (OR) for individuals in the highest vs the lowest quartile was 0.5 [95% confidence interval (CI) = 0.3-0.9]. We found an inverse association between dietary calcium and risk of adenomatous polyps, but the protective effect was present only for individuals in the fourth vs the first quartile (OR = 0.7; 95% CI = 0.3-1.3). Intake of total fat was positively associated with risk of adenomatous polyps, but we saw no consistent trend. Calcium intake appeared to modify the effect of total fat intake on the risk of adenomatous polyps.
我们开展了一项病例对照研究，以调查膳食纤维、钙和总脂肪与结直肠腺瘤性息肉风险之间的关系。我们使用食物频率问卷评估了157例病例和480名对照的日常饮食。在多变量分析中，膳食纤维与腺瘤性息肉风险呈负相关。最高四分位数与最低四分位数个体的比值比（OR）为0.5 [95%置信区间（CI）= 0.3 - 0.9]。我们发现饮食钙与腺瘤性息肉风险之间存在负相关，但仅在第四四分位数与第一四分位数个体中存在保护作用（OR = 0.7；95% CI = 0.3 - 1.3）。总脂肪摄入量与腺瘤性息肉风险呈正相关，但我们未观察到一致的趋势。钙摄入量似乎改变了总脂肪摄入量对腺瘤性息肉风险的影响。
