Jacobs R M, McCutcheon L J, Valli V E, Smith H E
Department of Pathology, Ontario Veterinary College, University of Guelph, Canada.
J Comp Pathol. 1996 Jan;114(1):23-30. doi: 10.1016/s0021-9975(96)80059-4.
Six yearling sheep were inoculated intraperitoneally with peripheral blood from two sheep infected with the bovine immunodeficiency-like virus (BIV) strain R29. An additional five sheep served as sham-inoculated controls. Of the six sheep given BIV, five seroconverted, one of them remaining seropositive for the duration of the study. The polymerase chain reaction demonstrated BIV provirus in three of the five serologically positive animals. At necropsy, 1 year after inoculation, histological changes were found only in the lymphoid tissues. In sheep exposed to BIV, mild though significant increases were seen in the (1) number of splenic periarteriolar lymphoid sheaths, (2) number of secondary follicles in hilar and prescapular or popliteal lymph nodes, and (3) medullary sinus cellularity in prescapular and popliteal lymph nodes.
将来自两只感染牛免疫缺陷样病毒（BIV）R29株的绵羊的外周血腹腔注射接种给6只一岁龄绵羊。另外5只绵羊作为假接种对照。在接受BIV接种的6只绵羊中，5只发生了血清转化，其中1只在研究期间一直保持血清阳性。聚合酶链反应在5只血清学阳性动物中的3只中检测到BIV前病毒。接种1年后尸检时，仅在淋巴组织中发现组织学变化。在接触BIV的绵羊中，观察到（1）脾动脉周围淋巴鞘数量、（2）肺门和肩胛前或腘淋巴结中二级滤泡数量以及（3）肩胛前和腘淋巴结髓窦细胞密度有轻微但显著增加。
