Salem N, Reyzer M, Karanian J
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20852, USA.
Lipids. 1996 Mar;31 Suppl:S153-6. doi: 10.1007/BF02637068.
This paper presents an animal model of alcoholism in which rats were exposed to alcohol by inhalation and were fed a diet that simulated the poor diet of some alcoholics. It is hypothesized that some of the pathophysiological effects of alcohol are related to its effects on essential fatty acid metabolism and composition of vital organs. A diet that contains no 20- and 22-carbon essential fatty acids and has low levels of 18-carbon essential fatty acids was used as a dietary challenge. Addition of a second metabolic challenge, i.e., alcohol, led to loss of tissue polyunsaturates, particularly liver arachidonate. A method of cycling alcohol inhalation for 12 h/d was also presented, which was also shown to lower liver arachidonic acid content.
本文介绍了一种酒精中毒动物模型，其中大鼠通过吸入接触酒精，并喂食模拟一些酗酒者不良饮食的食物。据推测，酒精的一些病理生理效应与其对必需脂肪酸代谢和重要器官组成的影响有关。一种不含20碳和22碳必需脂肪酸且18碳必需脂肪酸含量低的食物被用作饮食挑战。添加第二种代谢挑战，即酒精，导致组织多不饱和脂肪酸减少，尤其是肝脏花生四烯酸。还提出了一种每天循环吸入酒精12小时的方法，该方法也被证明可降低肝脏花生四烯酸含量。
