Schlüter-Wigger W, Elsner P
Department of Dermatology, University of Zurich, Switzerland.
Contact Dermatitis. 1996 Apr;34(4):278-83. doi: 10.1111/j.1600-0536.1996.tb02200.x.
Protective creams (PCs) play their part in the prevention of occupational contact dermatitis, even though efficacy data are frequently lacking. 4 different commercially-available PCs were evaluated against a set of 4 standard irritants (10% sodium lauryl sulfate (SLS), 1% sodium hydroxide (NaOH), 30% lactic acid (LA) and undiluted toluene (TOL)) in the repetitive irritation test (RIT) in humans described by Frosch and Kurte. 20 subjects were tested on the paravertebral skin on the mid-back. Irritation was assessed by visual scoring, transepidermal water loss (TEWL) as an indicator of epidermal barrier function, and colorimetry as a parameter of inflammation. Very different protective effects of the PCs on irritation by chemical substances were detectable. All products were very effective against SLS irritation. No PC provided significant protection against toluene. 3 products showed a partially protective effect against all ionic irritants, while the 4th showed less protection against SLS and NaOH, and even amplification of inflammation by TOL. Considering the range of PC effects from good protection to increased irritation, depending on the irritant, the need for careful selection of PCs for specific workplaces is stressed.
防护霜在预防职业性接触性皮炎方面发挥着作用，尽管常常缺乏疗效数据。针对Frosch和Kurte所描述的人体重复性刺激试验（RIT）中的一组4种标准刺激物（10%月桂醇硫酸酯钠（SLS）、1%氢氧化钠（NaOH）、30%乳酸（LA）和未稀释的甲苯（TOL）），对4种不同的市售防护霜进行了评估。20名受试者在中背部的椎旁皮肤进行测试。通过视觉评分、作为表皮屏障功能指标的经表皮水分流失（TEWL）以及作为炎症参数的比色法来评估刺激情况。可以检测到防护霜对化学物质刺激的防护效果差异很大。所有产品对SLS刺激都非常有效。没有一种防护霜能对甲苯提供显著保护。3种产品对所有离子性刺激物都有部分保护作用，而第4种产品对SLS和NaOH的保护作用较小，甚至甲苯会加剧炎症。考虑到防护霜的效果范围从良好保护到刺激加剧，具体取决于刺激物，强调了针对特定工作场所谨慎选择防护霜的必要性。
