Elsner P, Wigger-Alberti W, Pantini G
Department of Dermatology, Friedrich Schiller University, Jena, Germany.
Dermatology. 1998;197(2):141-5. doi: 10.1159/000017986.
Perfluoropolyethers (PFPEs) are non-reactive perfluorinated (no hydrogen atoms) liquid polymers that showed promise as ingredients of protective preparations in occupational dermatology.
The aim of this study was to investigate if oil-in-water (o/w) emulsions containing 0.5, 1.0, 2.0 and 4.0% PFPEs (molecular weight 6,250 D) prevent epidermal barrier disruption induced by a repetitive irritation test (RIT).
PFPE-containing o/w emulsions and the emulsion base alone were evaluated against a set of 4 irritants [10% sodium lauryl sulphate (SLS), 0.5% sodium hydroxide (NaOH), 15% lactic acid (LA), and undiluted toluene (TOL)] in the RIT. Ten subjects were tested on the paravertebral skin of the mid-back. Irritation was assessed by visual scoring, transepidermal water loss (TEWL) and colorimetry.
Both the emulsion base and all PFPE-containing preparations significantly suppressed irritation by SLS and NaOH. Against LA and TOL, only the 4% PFPE-containing preparation was significant as assessed by TEWL.
A 4% PFPE-containing o/w emulsion significantly inhibits irritation due to a wide spectrum of hydrophilic and lipophilic irritants. o/w emulsions with lower concentrations of PFPE are also effective against SLS and NaOH, but this is also true for the cream base alone. Therefore, further studies are necessary to evaluate if a minimum of 4% PFPE in the base provides additional benefit.
全氟聚醚（PFPEs）是无反应性的全氟化（无氢原子）液态聚合物，有望成为职业皮肤病学中防护制剂的成分。
本研究旨在调查含有0.5%、1.0%、2.0%和4.0% PFPEs（分子量6250 D）的水包油（o/w）乳液是否能预防重复刺激试验（RIT）诱导的表皮屏障破坏。
在RIT中，针对一组4种刺激物[10%月桂基硫酸钠（SLS）、0.5%氢氧化钠（NaOH）、15%乳酸（LA）和未稀释的甲苯（TOL）]评估含PFPEs的o/w乳液和单独的乳液基质。10名受试者在中背部的椎旁皮肤进行测试。通过视觉评分、经表皮水分流失（TEWL）和比色法评估刺激情况。
乳液基质和所有含PFPEs的制剂均显著抑制了SLS和NaOH引起的刺激。对于LA和TOL，通过TEWL评估，仅含4% PFPEs的制剂具有显著性。
含4% PFPEs的o/w乳液能显著抑制多种亲水性和亲脂性刺激物引起的刺激。较低浓度PFPEs的o/w乳液对SLS和NaOH也有效，但单独的乳膏基质也如此。因此，有必要进一步研究基础中至少4%的PFPE是否能带来额外益处。
