Elekes O, Venema K, Postema F, Dringen R, Hamprecht B, Korf J
Department of Biological Psychiatry, Groningen University, The Netherlands.
Neurosci Lett. 1996 Apr 12;208(1):69-72. doi: 10.1016/0304-3940(96)12553-2.
Extracellular lactate of the rat hippocampus is inter alia increased by immobilization stress. The origin of lactate is, however, not well established, so it is not known whether it is mainly derived form neurons or glial cells. Dialysates were collected shortly (1 or 2 days) or with a delay (14 or 15 days) after implantation of the probe. In the short-term experiment lactate increased after stress, both with or without glucose added to the perfusate. In the long-term experiment there was marked gliosis around the dialysis probe and the stress effects were seen only in the presence of 5 mM glucose. The results are consistent with the idea that stress induces glycogenolysis and lactate export from astroglial cells via neurotransmitter or hormonal related processes.
大鼠海马体的细胞外乳酸会因固定应激而增加。然而，乳酸的来源尚未完全明确，所以尚不清楚它主要是源自神经元还是神经胶质细胞。在植入探针后不久（1或2天）或延迟（14或15天）收集透析液。在短期实验中，无论灌注液中是否添加葡萄糖，应激后乳酸都会增加。在长期实验中，透析探针周围出现明显的神经胶质增生，且只有在存在5 mM葡萄糖的情况下才会出现应激效应。这些结果与应激通过神经递质或激素相关过程诱导星形胶质细胞糖原分解和乳酸输出的观点一致。
