全身型幼年特发性关节炎中发热与细胞因子网络的动态变化
Dynamics of fever and the cytokine network in systemic juvenile arthritis.
作者信息
Prieur A M, Roux-Lombard P, Dayer J M
机构信息
Pediatric Rheumatology Department, Enfants-Malades Teaching Hospital, Paris, France.
出版信息
Rev Rhum Engl Ed. 1996 Mar;63(3):163-70.
AIM OF THE STUDY
To determine the levels of the inflammatory cytokines IL1 alpha, IL1 beta, TNF alpha, IL6, IL8 and of their inhibitors TNF-sR55, TNF-s R75 and IL1-Ra during temperature elevation in systemic juvenile chronic arthritis.
METHODS
Fifty-six serum samples were collected at regular intervals from seven children during 8 fever cycles. Cytokine levels were determined using enzyme-linked immunoassays.
RESULTS
Levels of IL1 alpha, IL1 beta, TNF alpha and IL8 showed no variations. In contrast, IL6 and IL1-Ra levels paralleled the fever spikes. TNF-sR75 levels were also correlated with the fever.
CONCLUSION
Fever dynamics in systemic juvenile chronic arthritis may be partly related to cytokine variations.
研究目的
确定全身性幼年慢性关节炎体温升高期间炎性细胞因子IL1α、IL1β、TNFα、IL6、IL8及其抑制剂TNF-sR55、TNF-sR75和IL1-Ra的水平。
方法
在8个发热周期内，定期从7名儿童身上采集56份血清样本。使用酶联免疫吸附测定法测定细胞因子水平。
结果
IL1α、IL1β、TNFα和IL8水平无变化。相比之下，IL6和IL1-Ra水平与发热高峰平行。TNF-sR75水平也与发热相关。
结论
全身性幼年慢性关节炎的发热动态可能部分与细胞因子变化有关。
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