Dusser Perrine, Koné-Paut Isabelle
Paediatric Rheumatology Department, Université Paris-Saclay, APHP, Bicêtre Hospital, 94270 Le Kremlin-Bicêtre, France.
Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses Inflammatoire (CEREMAIA), Université Paris-Saclay, APHP, Bicêtre Hospital, 94270 Le Kremlin-Bicêtre, France.
J Clin Med. 2021 Jul 23;10(15):3244. doi: 10.3390/jcm10153244.
Still's disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. We present here a personal vision of what can link these two diseases, taking up their concepts at their beginning. By their many clinical and physiopathological similarities, we conclude that they constitute a common spectrum whose fate is modified by subtle differences in terms of adaptive response that could, in part, be driven by genetic factors.
如今，斯蒂尔病和川崎病（KD）属于细胞因子风暴综合征组，这是一组与先天免疫反应过度激活相关的病理生理情况。我们在此提出一种个人观点，阐述这两种疾病之间可能存在的联系，从它们最初的概念入手。鉴于它们在临床和生理病理方面存在诸多相似之处，我们得出结论，它们构成了一个共同的谱系，其发展结局因适应性反应方面的细微差异而有所改变，而这些差异部分可能由遗传因素驱动。
