[Influence of bile salts on the motor response of isolated ileum to acetylcholine, in rats].

UNLABELLED

Absence of bile salts in the intestinal lumen of jaundiced patients is associated to bacterial overgrowth and systemic endotoxemia. These bile salts, however, did not show significant influence on aerobic and facultative intestinal bacteria. The increasing bacterial colonization may be due to depressed intestinal motor response.

PURPOSE

To evaluate the influence of bile salts on intestinal motor response in presence of obstructive jaundice.

METHODS

We studied in vitro the motor response of ileal segments of 30 Holtzman rats divided into three groups (n = 10): washed ileum, intraluminal bile salts and exogenous oral bile salts administred during six days. Five animals of each group were submitted to sham operation and the other five were submitted to ligation and section of the common bile duct. A four centimeter ileal segment was isolated and studied through a dose-response assay with acetylcholine in an organ chamber.

RESULTS

The results showed an increased ileal affinity to acetylcholine in presence of intraluminal bile salts.

CONCLUSION

The intraluminal bile salts appear to exert in vitro a stimulatory effect on ileal motility.