Wang H, Sun B
Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical College, Xian.
Zhonghua Nei Ke Za Zhi. 1995 Dec;34(12):802-4.
To study the functional state as well as the relation-ship between eosinophil and T lymphocyte in the asthmatics, the authors measured the eosinophil density of blood with percoll, the level of serum eosinophil cation protein (ECP) with radioimmunoassay and soluble IL-2 receptor (sIL-2R) concentration with ELISA. The results revealed that the proportion of hypodense eosinophil and the levels of serum ECP and sIL-2R were 36.3% +/- 14.80%, 10.74 +/- 7.22 mg/L and 0.33% +/- 10 U/L respectively in asthmatics, being significantly higher than those in normal subjects (14.71% +/- 8.20%, 6.93 +/- 4.91 mg/L, 0.13 +/- 0.03 U/L, respectively, P < 0.05 in all). There is remarkable correlation between any two of the three parameters (r = 0.40, 0.37, 0.39, respectively, P < 0.05). It is suggested that eosinophil activation is associated with T lymphocyte activation, both may be involved in the pathogenesis of asthma.
为研究哮喘患者中嗜酸性粒细胞与T淋巴细胞的功能状态及其相互关系，作者采用Percoll法检测血液中嗜酸性粒细胞密度，用放射免疫法测定血清嗜酸性粒细胞阳离子蛋白（ECP）水平，用酶联免疫吸附测定法检测可溶性白细胞介素-2受体（sIL-2R）浓度。结果显示，哮喘患者中低密度嗜酸性粒细胞比例、血清ECP水平和sIL-2R浓度分别为36.3%±14.80%、10.74±7.22mg/L和0.33%±10U/L，显著高于正常受试者（分别为14.71%±8.20%、6.93±4.91mg/L、0.13±0.03U/L，P均<0.05）。这三个参数中的任意两个之间均存在显著相关性（r分别为0.40、0.37、0.39，P<0.05）。提示嗜酸性粒细胞活化与T淋巴细胞活化有关，二者可能均参与哮喘的发病机制。
