Ding X Z, Xiong S T, Li H, Zhang S X, Lü K Z
Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1995;15(4):238-41. doi: 10.1007/BF02887954.
Patients with obstructive jaundice have a high susceptibility to infection in the process of treatment and the reason for this is not fully understood. It was postulated that it may bear some relations to abnormalities of immune function. In this article, 28 cases of obstructive jaundice were selected to investigate alternation of monocyte immune function with the purpose of exploring mechanism of high susceptibility to infection from the perspective of immunology. The results showed that interleukin 1 production by monocytes significantly decreased and prostaglandin E2 increased, HLA-DR expression of monocytes was remarkably depressed. HLA-DR expression of monocytes was further decreased with recovery slower than non-jaundiced patients after operation. All this may be responsible for high susceptibility to infection in the process of treatment of obstructive jaundice.
梗阻性黄疸患者在治疗过程中对感染具有高度易感性，其原因尚未完全明确。据推测，这可能与免疫功能异常有关。本文选取28例梗阻性黄疸患者，研究单核细胞免疫功能的变化，旨在从免疫学角度探讨感染高度易感性的机制。结果显示，单核细胞产生的白细胞介素1显著减少，前列腺素E2增加，单核细胞的HLA-DR表达明显降低。术后单核细胞的HLA-DR表达进一步下降，恢复速度比非黄疸患者慢。所有这些可能是梗阻性黄疸治疗过程中感染高度易感性的原因。
