Lutz E, Ward K N, Szydlo R, Goldman J M
Department of Virology, Royal Postgraduate Medical School, University of London, England.
J Med Virol. 1996 May;49(1):61-5. doi: 10.1002/(SICI)1096-9071(199605)49:1<61::AID-JMV10>3.0.CO;2-5.
The reconstitution of the human cytomegalovirus (CMV) antibody response in CMV seropositive bone marrow transplant patients was investigated by comparing 11 patients whose donors were CMV seropositive with 8 whose donors were CMV seronegative. Evidence for primary or secondary responses to CMV was sought by determining IgG antibody avidity using an avidity index method, and antibody titre over a period of up to 3 years after transplant. For the patients whose donors were CMV seropositive, the results showed the characteristics of a secondary response, i.e., rising antibody titres of high avidity immediately after transplant. In contrast, the patients with CMV seronegative donors showed evidence of a primary antibody response usually occurring at about 250 days after transplant, i.e., rising antibody levels initially of low avidity maturing to high avidity over the following 100 to 200 days. It is concluded that a secondary response and hence transfer of humoral immunity had occurred in those patients whose donor was CMV seropositive, whereas a delayed primary response occurred in those patients whose donor was CMV seronegative.
通过比较11名供体为巨细胞病毒（CMV）血清阳性的患者和8名供体为CMV血清阴性的患者，研究了CMV血清阳性骨髓移植患者中人类巨细胞病毒抗体反应的重建情况。通过使用亲和力指数法测定IgG抗体亲和力，并在移植后长达3年的时间内检测抗体滴度，来寻找对CMV的初次或二次反应的证据。对于供体为CMV血清阳性的患者，结果显示出二次反应的特征，即移植后立即出现高亲和力抗体滴度上升。相比之下，供体为CMV血清阴性的患者显示出初次抗体反应的证据，通常发生在移植后约250天，即抗体水平最初较低，在接下来的100至200天内逐渐成熟为高亲和力。结论是，供体为CMV血清阳性的患者发生了二次反应，从而实现了体液免疫的转移，而供体为CMV血清阴性的患者则发生了延迟的初次反应。
