Baur X, Seemann U, Marczynski B, Chen Z, Raulf-Heimsoth M
Professional Associations' Institute of Occupational Medicine, Institute at the Ruhr University of Bochum, Germany.
Am J Ind Med. 1996 May;29(5):467-73. doi: 10.1002/(SICI)1097-0274(199605)29:5<467::AID-AJIM5>3.0.CO;2-J.
Two workers (23 and 28 years old) developed rhinitis and bronchial asthma after occupational contact with the isocyanate MDI. Positive skin prick test results for MDI-HSA and IgE antibodies to all isocyanate-HSA conjugates were obtained in both cases, and the inhalation challenge test with MDI produced immediate and late asthmatic reactions. In the patch test and the stimulation assay of peripheral mononuclear blood cells, a specific sensitization to the diamine MDA (in both cases) and to further amines (in one case), as well as to hydrolysates of the respective diisocyanates, was seen, which appears to be independent of the IgE response to isocyanate-HSA conjugates. Our results offer evidence of IgE-mediated, as well as lymphocyte, responses induced by exposures to isocyanate products over several months or years.
两名工人（分别为23岁和28岁）在职业接触异氰酸酯MDI后出现鼻炎和支气管哮喘。两例均获得了针对MDI-HSA的阳性皮肤点刺试验结果以及针对所有异氰酸酯-HSA偶联物的IgE抗体，并且用MDI进行的吸入激发试验产生了即刻和迟发性哮喘反应。在斑贴试验和外周血单个核细胞刺激试验中，发现对二胺MDA（两例均有）、其他胺类（一例）以及相应二异氰酸酯的水解产物存在特异性致敏，这似乎与对异氰酸酯-HSA偶联物的IgE反应无关。我们的结果证明了数月或数年接触异氰酸酯产品可诱导IgE介导的反应以及淋巴细胞反应。
