Cohen O, Yaniv R, Karasik A, Trau H
Institute of Endocrinology, C. Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel.
Med Hypotheses. 1996 Apr;46(4):348-50. doi: 10.1016/s0306-9877(96)90184-x.
Necrobiosis lipoidica diabeticorum is a rare skin disorder, usually considered a marker for diabetes mellitus. More than half of the patients with necrobiosis lipoidica diabeticorum have diabetes mellitus, but less than one per cent of diabetes mellitus patients have necrobiosis lipoidica diabeticorum. In the diabetes and dermatology literature, we find the position that there is no effect of glucose control on either the appearance of necrobiosis lipoidica diabeticorum or the clinical course of the lesion. We base our challenge to this position on a critical review of the original data. And conclude on the contrary, that necrobiosis lipoidica diabeticorum is usually associated with poor glucose control and that tighter glucose control, as currently practised, might improve or prevent the disorder.
糖尿病性类脂质渐进性坏死是一种罕见的皮肤疾病，通常被视为糖尿病的一个标志。超过半数的糖尿病性类脂质渐进性坏死患者患有糖尿病，但糖尿病患者中患糖尿病性类脂质渐进性坏死的不到1%。在糖尿病和皮肤病学文献中，我们发现这样一种观点，即血糖控制对糖尿病性类脂质渐进性坏死的外观或病变的临床病程均无影响。我们基于对原始数据的批判性回顾对这一观点提出质疑。相反，我们得出结论，糖尿病性类脂质渐进性坏死通常与血糖控制不佳有关，而目前所采用的更严格的血糖控制可能会改善或预防这种疾病。
