Bloch N, Breen M, Irvin Z V, Spradbrow P B
Department of Veterinary Pathology, University of Queensland, Australia.
Vet Rec. 1996 Apr 27;138(17):414-6. doi: 10.1136/vr.138.17.414.
A lesion on the head of a steer, defined histologically as an epithelial papilloma, yielded DNA which did not hybridise with any of the bovine papillomavirus DNAs usually associated with the formation of skin lesions. DNA from the lesion did hybridise with DNA from bovine papillomavirus 4, even under stringent conditions, and contained a sequence that could be amplified by polymerase chain reaction with primers specific for that virus. Bovine papillomavirus 4 had previously been isolated only from lesions of the upper alimentary canal.
一头阉牛头部的一处病变，经组织学定义为上皮乳头瘤，其产生的DNA不能与通常与皮肤病变形成相关的任何牛乳头瘤病毒DNA杂交。该病变的DNA甚至在严格条件下也能与牛乳头瘤病毒4的DNA杂交，并且包含一个可通过针对该病毒的特异性引物进行聚合酶链反应扩增的序列。牛乳头瘤病毒4此前仅从上消化道病变中分离得到。
