Northoff G, Wenke J, Pflug B
Department of Psychiatry, University of Frankfurt, Germany.
Psychol Med. 1996 May;26(3):547-53. doi: 10.1017/s0033291700035625.
We investigated serum creatine phosphokinase (CPK) and associated parkinsonic (SEPS) and dyskinetic (AIMS) movements in 32 hospital admitted acute catatonic patients. Thirty-two (N = 24 without neuroleptics on admission) catatonic patients were compared with 32 non-catatonic dyskinetic psychiatric patients, 32 non-catatonic non-dyskinetic psychiatric patients and 32 healthy controls. CPK was significantly higher (P = 0.015) in catatonics (mean 255.75, S.D. +/- 226.54) than in healthy controls (38.6, +/- 27.4) and non-catatonic non-dyskinetic psychiatric patients (57.1, +/- 120.8) whereas there was no significant difference between catatonics and non-catatonic dyskinetic psychiatric patients (453.4, +/- 128.5). There were significantly positive correlations between CPK and AIMS, as well as significantly negative correlations between CPK and SEPS, in all three groups. Our results suggest that increased serum CPK in catatonia may be related to occurrence of dyskinetic movements. Furthermore, we were able to distinguish a parkinsonic (low CPK, low AIMS, high SEPS) and a dyskinetic (high CPK, high AIMS, low SEPS) subtype in catatonia.
我们调查了32名住院的急性紧张症患者的血清肌酸磷酸激酶（CPK）以及相关的帕金森样（SEPS）和运动障碍（AIMS）运动情况。将32名（其中24名入院时未使用抗精神病药物）紧张症患者与32名非紧张症性运动障碍精神病患者、32名非紧张症性非运动障碍精神病患者以及32名健康对照者进行了比较。紧张症患者的CPK水平（均值255.75，标准差±226.54）显著高于健康对照者（38.6，±27.4）和非紧张症性非运动障碍精神病患者（57.1，±120.8）（P = 0.015），而紧张症患者与非紧张症性运动障碍精神病患者（453.4，±128.5）之间无显著差异。在所有三组中，CPK与AIMS之间存在显著正相关，CPK与SEPS之间存在显著负相关。我们的结果表明，紧张症患者血清CPK升高可能与运动障碍的发生有关。此外，我们能够在紧张症中区分出帕金森样亚型（CPK低、AIMS低、SEPS高）和运动障碍亚型（CPK高、AIMS高、SEPS低）。
