特应性皮炎患者可溶性细胞间黏附分子-1和可溶性E选择素水平

Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis.

作者信息

Hirai S, Kageshita T, Kimura T, Tsujisaki M, Okajima K, Imai K, Ono T

机构信息

Department of Dermatology, Kumamoto University School of Medicine, Japan.

出版信息

Br J Dermatol. 1996 Apr;134(4):657-61. doi: 10.1111/j.1365-2133.1996.tb06965.x.

DOI:10.1111/j.1365-2133.1996.tb06965.x

PMID:8733366

Abstract

The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) were determined by double determinant immunoassay (DDIA), in 37 patients with atopic dermatitis (AD) and 31 age- and sex-matched healthy control subjects. Both sICAM-1 and sE-selectin levels were significantly higher in patients with AD than in healthy controls (P < 0.01), and were correlated with disease severity. A longitudinal study of patients with AD revealed that the levels of sICAM-1 decreased in those in whom symptoms improved. The sICAM-1 levels were significantly correlated with those of sE-selectin. Our studies suggest that such high levels of serum sICAM-1 and sE-selectin may affect the immune response in patients with AD. The levels of sICAM-1 and sE-selectin may be a useful immunological parameter for monitoring disease activity in AD.

摘要

采用双检测免疫分析法（DDIA）测定了37例特应性皮炎（AD）患者和31例年龄及性别匹配的健康对照者血清中可溶性细胞间黏附分子-1（sICAM-1）和可溶性E-选择素（sE-选择素）的水平。AD患者的sICAM-1和sE-选择素水平均显著高于健康对照者（P < 0.01），且与疾病严重程度相关。对AD患者的一项纵向研究显示，症状改善的患者sICAM-1水平下降。sICAM-1水平与sE-选择素水平显著相关。我们的研究表明，如此高的血清sICAM-1和sE-选择素水平可能会影响AD患者的免疫反应。sICAM-1和sE-选择素水平可能是监测AD疾病活动的有用免疫学参数。