Bracken W M, Cuppage F, McLaury R L, Kirwin C, Klaassen C D
J Occup Med. 1985 Oct;27(10):733-9.
Hydrofluoric acid (HF) burns are characterized by progressive tissue necrosis and severe pain. Numerous topical treatments have been proposed, yet few have been studied experimentally. The present study was designed to examine the comparative efficacy of recommended treatments. Hair on the hind legs of rats was removed and 48 hours later 70% HF was applied. Calcium gluconate, Zephiran (benzalkonium chloride), A + D Ointment, aloe gel, and magnesium ointment were applied topically and burn development was monitored. Calcium gluconate significantly reduced burn size as early as one hour after application. Significant protection continued for seven days after the single application. The other treatments were not effective in decreasing or delaying HF burn development. The results indicated that calcium gluconate ointment was the most effective topical treatment for HF burns.
氢氟酸（HF）灼伤的特点是组织进行性坏死和剧痛。人们提出了许多局部治疗方法，但很少进行实验研究。本研究旨在检验推荐治疗方法的相对疗效。去除大鼠后腿的毛发，48小时后涂抹70%的氢氟酸。局部应用葡萄糖酸钙、新洁尔灭（苯扎氯铵）、A+D软膏、芦荟凝胶和镁软膏，并监测灼伤的发展情况。葡萄糖酸钙在应用后1小时就显著减小了灼伤面积。单次应用后，显著的保护作用持续了7天。其他治疗方法在减少或延缓氢氟酸灼伤发展方面无效。结果表明，葡萄糖酸钙软膏是治疗氢氟酸灼伤最有效的局部治疗方法。
