Therrell B L, Hannon W H, Pass K A, Lorey F, Brokopp C, Eckman J, Glass M, Heidenreich R, Kinney S, Kling S, Landenburger G, Meaney F J, McCabe E R, Panny S, Schwartz M, Shapira E
Bureau of Laboratories, Texas Department of Health, Austin 78756, USA.
Biochem Mol Med. 1996 Apr;57(2):116-24. doi: 10.1006/bmme.1996.0017.
These guidelines provide scientific information for policy development by state health departments considering appropriate use of newborn screening specimens after screening tests are finished. Information was collected, debated, and formulated into a policy statement by the Newborn Screening Committee of the Council of Regional Networks for Genetic Services (CORN), a federally funded national consortium of representatives from 10 regional genetics networks. Newborn screening programs vary widely in approaches and policies concerning residual dried blood spot samples (DBS) collected for newborn screening. Recognition of the epidemiological utility of DBS samples for HIV seroprevalence surveys and a growing interest in DBSs for DNA analysis has intensified consideration of issues regarding retention, storage, and use of residual DBS samples. Potentially these samples provide a genetic material "bank" for all newborns nationwide. Their values as a resource for other uses has already been recognized by scientists, administrators, and judicial officials. Programs should promulgate rules for retention and use of residual newborn screening DBS samples based on scientifically valid information. Banking of newborn samples as sources of genetic material should be considered in light of potential benefit or harm to society.
这些指南为州卫生部门制定政策提供科学信息，这些政策涉及在筛查测试完成后对新生儿筛查样本的适当使用。信息由遗传服务区域网络理事会（CORN）的新生儿筛查委员会收集、讨论并形成政策声明，CORN是一个由联邦资助的全国性联盟，由来自10个区域遗传网络的代表组成。新生儿筛查项目在收集用于新生儿筛查的残余干血斑样本（DBS）的方法和政策上差异很大。对DBS样本在HIV血清流行率调查中的流行病学效用的认识以及对用于DNA分析的DBS样本的兴趣日益浓厚，这加剧了对残余DBS样本的留存、储存和使用问题的考虑。这些样本有可能为全国所有新生儿提供一个遗传物质“库”。科学家、管理人员和司法官员已经认识到它们作为其他用途资源的价值。各项目应根据科学有效的信息颁布关于留存和使用残余新生儿筛查DBS样本的规则。鉴于对社会可能带来的益处或危害，应考虑将新生儿样本作为遗传物质来源进行储存。
