N'gouemo P, Baldy-Moulinier M, Nguemby-Bina C
Laboratoire de Médecine Expérimentale, INSERM U249-CNRS UPR9008, Montpellier, France.
J Ethnopharmacol. 1996 Jun;52(2):77-83. doi: 10.1016/0378-8741(96)01389-x.
This study investigates some pharmacological effects of the ethanolic extract of the leaves of Desmodium adscendens (Papillionaceae), a medicinal plant in the African traditional medicine, on the central nervous system. The plant extract induced hypothermia and had analgesic effect in mice. D. adscendens suppressed the tonic phase of convulsion and mortality induced by pentylenetetrazole (PTZ) in mice. In addition, the plant extract delayed the onset of PTZ forelimb clonus, and generalized limbic seizures induced by kainic acid. In contrast, the plant extract did not affect either tonic convulsion induced by maximal electroshock in mice or the progression of limbic seizures towards the status epilepticus in rats.
本研究调查了非洲传统医学中的药用植物攀援山蚂蝗（豆科）叶片乙醇提取物对中枢神经系统的一些药理作用。该植物提取物可诱导小鼠体温过低并具有镇痛作用。攀援山蚂蝗抑制了小鼠戊四氮（PTZ）诱导的惊厥强直期和死亡率。此外，该植物提取物延迟了PTZ前肢阵挛的发作以及海人酸诱导的全身性边缘叶癫痫发作。相比之下，该植物提取物对小鼠最大电休克诱导的强直性惊厥或大鼠边缘叶癫痫向癫痫持续状态的进展均无影响。
