N'Gouemo P, Pambou-Tchivounda H, Baldy-Moulinier M, Koudogbo B, N'Guemby-Bina C
Laboratoire de Médecine Expérimentale, INSERM U249-CNRS UPR9008, Institut de Biologie, Montpellier, France.
Planta Med. 1994 Aug;60(4):305-7. doi: 10.1055/s-2006-959489.
The present study investigates some neuropharmacological effects of an ethanolic extract of the leaves of Trema guineensis (Ulmaceae), a medicinal plant of central Africa. Intraperitoneal administration of the extract induced hypothermia. In addition, the extract significantly shortened the latency to sleep and prolonged the duration of sleeping time induced by sodium pentobarbital in mice. Moreover, T. guineensis significantly delayed the onset of clonic seizures induced by pentylenetetrazole in mice. In contrast, T. guineensis did not affect convulsions induced by maximal electroshock and picrotoxin in mice nor status epilepticus produced by pilocarpine and kainic acid in rats.
本研究调查了非洲中部药用植物几内亚山黄麻（榆科）叶乙醇提取物的一些神经药理学作用。腹腔注射该提取物可引起体温过低。此外，该提取物显著缩短了小鼠戊巴比妥钠诱导的入睡潜伏期，并延长了睡眠时间。而且，几内亚山黄麻显著延迟了小鼠戊四氮诱导的阵挛性惊厥的发作。相反，几内亚山黄麻对小鼠最大电休克和印防己毒素诱导的惊厥以及大鼠毛果芸香碱和 kainic 酸诱导的癫痫持续状态均无影响。
