人类志愿者和抑郁症患者血浆及血小板中神经肽Y样免疫反应性的差异。
Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients.
作者信息
Nilsson C, Karlsson G, Blennow K, Heilig M, Ekman R
机构信息
Department of Neurochemistry, University of Göteborg, Mölndal, Sweden.
出版信息
Peptides. 1996;17(3):359-62. doi: 10.1016/0196-9781(96)00013-7.
In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet-poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.
在本研究中，与对照组相比，复发性重度抑郁症患者的少血小板血浆中神经肽Y样免疫反应性（NPY-LI）显著降低（p<0.01），而血小板中的NPY-LI显著升高（p<0.001）。此外，当通过高效液相色谱（HPLC）分析样品，随后对收集的馏分进行放射免疫分析（RIA）时，发现少血小板血浆（PPP）和血小板中NPY-LI存在定性差异。
Zotero 插件