实验性肺炎支原体疾病的免疫预防：给药途径对灭活肺炎支原体疫苗免疫原性和保护作用的影响
Immunoprophylaxis of experimental Mycoplasma pneumoniae disease: effect of route of administration on the immunogenicity and protective effect of inactivated M. pneumoniae vaccine.
作者信息
Greenberg H, Helms C M, Grizzard M B, James W D, Horswood R L, Chanock R M
出版信息
Infect Immun. 1977 Apr;16(1):88-92. doi: 10.1128/iai.16.1.88-92.1977.
Abstract
Formalin-inactivated Mycoplasma pneumoniae vaccine was administered subcutaneously or intranasally to hamsters to examine the effect of route of administration on immunogenicity and protective effect. Parenterally administered vaccine in the doses employed induced serum complement-fixing antibody formation, but did not significantly decrease the frequency of pneumonia following challenge with virulent M. pneumoniae. Intranasally instilled vaccine was ineffective in stimulating serum antibody, but did diminish the frequency of experimentally induced pneumonia due to M. pneumoniae. However, a greater degree of resistance was induced by intranasal infection with either wild-type organisms or the ts 640 attenuated mutant of M. pneumoniae.
摘要
将福尔马林灭活的肺炎支原体疫苗经皮下或鼻内途径接种给仓鼠，以研究接种途径对免疫原性和保护效果的影响。采用的剂量经肠胃外途径接种疫苗可诱导血清补体结合抗体形成，但在用强毒肺炎支原体攻击后，并未显著降低肺炎的发生率。经鼻内滴注的疫苗在刺激血清抗体方面无效，但确实降低了由肺炎支原体引起的实验性诱导肺炎的发生率。然而，野生型菌株或肺炎支原体ts 640减毒突变株经鼻内感染诱导了更高程度的抵抗力。
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Immunoprophylaxis of experimental Mycoplasma pneumoniae disease: effect of route of administration on the immunogenicity and protective effect of inactivated M. pneumoniae vaccine.实验性肺炎支原体疾病的免疫预防：给药途径对灭活肺炎支原体疫苗免疫原性和保护作用的影响
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