White F V, Jordan J, Dickman P S, Knisely A S
Department of Pathology, Children's Hospital, Boston, Massachusetts, USA.
Pediatr Pathol Lab Med. 1995 Jan-Feb;15(1):121-9. doi: 10.3109/15513819509026944.
Fetal parvovirus B19 infection has been reported in association with hydrops and fetal demise, myocarditis, and congenital anomalies, as well as with normal outcome of pregnancy. One infant with liver disease of fetal onset associated with parvovirus B19 infection has been described. We have seen another such infant, in whom marked siderosis of the liver suggested accelerated destruction of erythrocytes and portal tract fibrosis with proliferation of bile ducts suggested intrauterine infection. Viral cytopathic effects were not seen. Maternal serum obtained postpartum contained IgM class antibodies against parvovirus B19, and parvovirus B19 nucleic acid sequences were identified in the infant's liver by polymerase chain reaction studies. We propose that recognition of this combination of siderosis with fibrosis and bile duct proliferation will permit identification of cases of fetal parvovirus B19 infection.
据报道，胎儿细小病毒B19感染与胎儿水肿、胎儿死亡、心肌炎、先天性畸形有关，也与正常妊娠结局有关。曾有一例与细小病毒B19感染相关的胎儿期起病的肝病婴儿被描述。我们又见到了另一例这样的婴儿，其肝脏有明显的含铁血黄素沉着提示红细胞加速破坏，门管区纤维化伴胆管增生提示宫内感染。未见到病毒细胞病变效应。产后获得的母体血清中含有抗细小病毒B19的IgM类抗体，通过聚合酶链反应研究在婴儿肝脏中鉴定出细小病毒B19核酸序列。我们认为，认识到这种含铁血黄素沉着与纤维化及胆管增生的组合将有助于识别胎儿细小病毒B19感染病例。
