Anilkumar T K, Karpurkar S A, Shinde V S
Dept of Anaesthesiology, KEM Hospital, Parel, Bombay.
J Postgrad Med. 1994 Apr-Jun;40(2):61-4.
Eighty-five paediatric patients (age range: 6 mths-12yrs) undergoing lower abdominal surgery were studied for post-operative pain relief following either caudal bupivacaine (GpI: n = 43) or buprenorphine (GpII: n = 42). Bupivacaine was administered as 0.5ml/kg body weight of 0.25% solution and buprenorphine as 4 micrograms/ml and volume of 0.5 ml/Kg body weight in normal saline. Post-operatively pain was graded on a 4-point scale and behaviour on a 5-point scale. Any post-operative complications and need for additional analgesia were also noted. Bupivacaine provided good pain relief in the early post-operative hours but buprenorphine provided pain relief lasting for 24 hrs or more post-operatively. Post-operative behaviour of 10 patients receiving buprenorphine was graded as cheerful as compared to 2 from bupivacaine group. Till the end of observation period (i.e. 8 hr post-operatively), majority of patients receiving buprenorphine remained cheerful.
对85例接受下腹部手术的儿科患者(年龄范围:6个月至12岁)进行了研究,比较了尾骶部注射布比卡因(第一组:n = 43)或丁丙诺啡(第二组:n = 42)后的术后疼痛缓解情况。布比卡因按0.25%溶液0.5ml/kg体重给药,丁丙诺啡按4微克/毫升、0.5ml/kg体重的剂量溶于生理盐水中给药。术后疼痛采用4分制评分,行为采用5分制评分。还记录了任何术后并发症和额外镇痛的需求。布比卡因在术后早期提供了良好的疼痛缓解,但丁丙诺啡在术后提供了持续24小时或更长时间的疼痛缓解。接受丁丙诺啡的10例患者的术后行为评分为愉悦,而布比卡因组为2例。直到观察期结束(即术后8小时),大多数接受丁丙诺啡的患者仍保持愉悦。