Salvati M, Cervoni L, Artico M
Neurological Mediterranean, Neuromed Institute, IRCCS, Pozzilli (Is), Italy.
Childs Nerv Syst. 1996 May;12(5):266-9. doi: 10.1007/BF00261808.
The authors review three personal cases of patients who developed cerebral meningiomas following high-dose radiotherapy for acute lymphoblastic leukemia. Two patients were female and one male. Their ages when the leukemia appeared were between 11 and 15 years. All patients were treated with a course of prophylactic irradiation to the neuraxis for a total dose of 24 Gy. After an average interval of 10.4 years, all three patients presented a meningioma; histologically, one was meningothelial and two were fibrous. All three meningiomas presented atypical features. At follow-up 1, 4, and 4 years respectively after surgery, none of these patients presents neurological deficits or neuroradiological signs of recurrence. Forty-nine cases of high-dose radiation-induced meningioma are also reviewed.
作者回顾了3例急性淋巴细胞白血病患者在接受大剂量放疗后发生脑脑膜瘤的个人病例。2例为女性，1例为男性。他们患白血病时的年龄在11至15岁之间。所有患者均接受了一轮针对神经轴的预防性照射，总剂量为24 Gy。平均间隔10.4年后，所有3例患者均出现了脑膜瘤；组织学上，1例为脑膜内皮型，2例为纤维型。所有3例脑膜瘤均表现出非典型特征。分别在术后1年、4年和4年进行随访时，这些患者均未出现神经功能缺损或复发的神经放射学征象。还回顾了49例高剂量辐射诱发的脑膜瘤病例。
