Norris D G, Niendorf T
Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany.
NMR Biomed. 1995 Nov-Dec;8(7-8):280-8. doi: 10.1002/nbm.1940080703.
This review examines the effect of experimental conditions on the data obtainable from diffusion weighted NMR experiments. The origin and forms of the Stejskal-Tanner experiment are presented, and the relative merits of bipolar to monopolar diffusion weighting gradient pulses are discussed, as are those of spin-echo and stimulated-echo weighting schemes. The short pulse Stejskal-Tanner experiment as required for q-space imaging is described. Criteria for successful diffusion weighted imaging are given, and current strategies for diffusion weighted imaging are evaluated against these. The range of biological objects accessible to diffusion weighted NMR is summarized, together with the associated experimental limitations. In the final section the dependence of diffusion weighted NMR data on diffusion time and b-value range is examined, and the relationship between apparent restricted diffusion and the size of the extracellular space is demonstrated.
本综述考察了实验条件对扩散加权核磁共振实验可获取数据的影响。介绍了斯泰伊卡尔-坦纳实验的起源和形式，讨论了双极与单极扩散加权梯度脉冲的相对优点，以及自旋回波和受激回波加权方案的相对优点。描述了q空间成像所需的短脉冲斯泰伊卡尔-坦纳实验。给出了成功进行扩散加权成像的标准，并据此评估了当前的扩散加权成像策略。总结了扩散加权核磁共振可研究的生物对象范围以及相关的实验限制。在最后一部分，考察了扩散加权核磁共振数据对扩散时间和b值范围的依赖性，并证明了表观受限扩散与细胞外空间大小之间的关系。
