Nicolay K, van der Toorn A, Dijkhuizen R M
Department of in vivo NMR, Utrecht University, The Netherlands.
NMR Biomed. 1995 Nov-Dec;8(7-8):365-74. doi: 10.1002/nbm.1940080710.
This review describes in vivo NMR measurements of metabolite diffusion. NMR spectroscopy can employ a variety of endogenous marker molecules to obtain information on various aspects of in vivo biochemistry and biophysics from the diffusion characteristics of these markers. NMR-based metabolite diffusion data give an insight into the physico-chemical properties of the intracellular compartment and of changes therein in relation to development and pathology. Recent applications have proven that in vivo diffusion spectroscopy provides exciting opportunities to both fundamental and applied research.
本综述描述了代谢物扩散的体内核磁共振测量。核磁共振光谱法可以使用多种内源性标记分子，从这些标记物的扩散特性中获取有关体内生物化学和生物物理学各个方面的信息。基于核磁共振的代谢物扩散数据有助于深入了解细胞内区室的物理化学性质及其在发育和病理过程中的变化。最近的应用证明，体内扩散光谱法为基础研究和应用研究都提供了令人兴奋的机会。
