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垂直捆绑胃成形术治疗肥胖症前后的胃食管反流

Gastro-oesophageal reflux before and after vertical banded gastroplasty in the treatment of obesity.

作者信息

Näslund E, Granström L, Melcher A, Stockeld D, Backman L

机构信息

Department of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm, Sweden.

出版信息

Eur J Surg. 1996 Apr;162(4):303-6.

PMID:8739417
Abstract

OBJECTIVE

To study the long term effect of vertical banded gastroplasty on lower oesophageal sphincter pressure.

DESIGN

Prospective study.

SETTING

University hospital, Sweden.

SUBJECTS

21 morbidly obese patients (mean body mass index 42.5).

INTERVENTIONS

Vertical banded gastroplasty, together with measurements of endoscopic grade, oesophageal manometry, and 24 hour pH before, and a mean of 38 months after, operation.

MAIN OUTCOME MEASURES

Weight, grade of oesophagitis according to the Savary-Miller classification, number of episodes of reflux, percentage of time that the pH was < 4, and lower oesophageal sphincter pressure.

RESULTS

Before operation 5/14 patients (36%) had evidence of oesophagitis, and 12/21 (57%) had evidence of reflux disease. Two patients had abnormally low lower oesophageal sphincter pressure ( < 10 mm Hg). A mean (SEM) of 32 months after operation (range 6-49) the mean body mass index was 32.7 (1.2), and after a mean of 38 months paired data showed that there had been no significant changes in manometric (n = 11) or 24 hour pH (n = 10) measurements, or in endoscopic grading (n = 7).

CONCLUSION

Vertical banded gastroplasty used in the treatment of morbid obesity does not affect the antireflux function of the lower oesophageal sphincter.

摘要

目的

研究垂直捆绑胃成形术对食管下括约肌压力的长期影响。

设计

前瞻性研究。

地点

瑞典大学医院。

研究对象

21例病态肥胖患者(平均体重指数42.5)。

干预措施

垂直捆绑胃成形术,同时在手术前及术后平均38个月时测量内镜分级、食管测压和24小时食管pH值。

主要观察指标

体重、根据Savary-Miller分类法的食管炎分级、反流发作次数、pH值<4的时间百分比以及食管下括约肌压力。

结果

术前14例患者中有5例(36%)有食管炎证据,21例中有12例(57%)有反流病证据。2例患者食管下括约肌压力异常低(<10 mmHg)。术后平均(SEM)32个月(范围6 - 49个月)时平均体重指数为32.7(1.2),术后平均38个月时配对数据显示测压(n = 11)、24小时食管pH值测量(n = 10)或内镜分级(n = 7)均无显著变化。

结论

用于治疗病态肥胖的垂直捆绑胃成形术不影响食管下括约肌的抗反流功能。

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