Kutteh W H, Ermel L D
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas 75235-9032, USA.
Am J Reprod Immunol. 1996 Apr;35(4):402-7. doi: 10.1111/j.1600-0897.1996.tb00501.x.
This study was conducted to determine if lower dose heparin (LD Heparin) combined with aspirin is as efficacious as higher dose heparin (HD Heparin) for the treatment of the antiphospholipid antibody syndrome in women seeking pregnancy. The method of the study was a prospective, single center trial including 50 patients who were consecutively assigned to treatment. Each patient had at least three consecutive, spontaneous pregnancy losses, positive antiphospholipid antibodies on two occasions, and a complete evaluation. Data were compared using Fisher's exact test. Viable infants were delivered from 20/25 (80%) women treated with higher dose heparin vs. 19/25 (76%) of women treated with lower dose heparin. There were no significant differences between groups with respect to gestational age at the time of delivery (37.2 +/- 3.4 versus 37.7 +/- 1.6 weeks), maternal complications, or fetal complications. A lower dose of heparin plus aspirin was as effective as higher dose heparin for the treatment of antiphospholipid antibody-associated recurrent pregnancy loss.
本研究旨在确定低剂量肝素（LD肝素）联合阿司匹林治疗寻求妊娠的抗磷脂抗体综合征女性是否与高剂量肝素（HD肝素）同样有效。本研究方法为前瞻性单中心试验，纳入50例连续入选接受治疗的患者。每位患者至少有3次连续自然流产史，两次抗磷脂抗体检测呈阳性，且经过全面评估。数据采用Fisher精确检验进行比较。接受高剂量肝素治疗的25名女性中有20名（80%）分娩出存活婴儿，而接受低剂量肝素治疗的25名女性中有19名（76%）分娩出存活婴儿。两组在分娩时的孕周（37.2±3.4周与37.7±1.6周）、母体并发症或胎儿并发症方面无显著差异。低剂量肝素加阿司匹林治疗抗磷脂抗体相关复发性流产与高剂量肝素同样有效。
