Kutteh W H
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas 75235-9032, USA.
Am J Obstet Gynecol. 1996 May;174(5):1584-9. doi: 10.1016/s0002-9378(96)70610-5.
The purpose of this study was to compare the use of low-dose aspirin alone with heparin and low-dose aspirin in the treatment of the antiphospholipid antibody syndrome.
A prospective, single-center trial included 50 patients who were alternately assigned to treatment. Each patient had at least three consecutive spontaneous pregnancy losses, positive antiphospholipid antibodies on two occasions, and a complete evaluation. Data were compared by chi(2) analysis and Fisher's exact test.
Viable infants were delivered of 11 of 25 (44%) women treated with aspirin and 20 of 25 (80%) women treated with heparin and aspirin (p < 0.05). There were no significant differences between the low-dose aspirin and the heparin plus low-dose aspirin groups with respect to gestational age at delivery (37.8 +/- 2.1 vs 37.2 +/- 3.4 weeks), number of cesarean sections (18% vs 20%), or complications.
Heparin plus low-dose aspirin provides a significantly better pregnancy outcome than low-dose aspirin alone does for antiphospholipid antibody-associated recurrent pregnancy loss.
本研究旨在比较单独使用低剂量阿司匹林与肝素联合低剂量阿司匹林治疗抗磷脂抗体综合征的效果。
一项前瞻性单中心试验纳入了50例患者，这些患者被交替分配接受治疗。每位患者至少有连续三次自然流产史，两次抗磷脂抗体检测呈阳性，并进行了全面评估。数据通过卡方分析和Fisher精确检验进行比较。
接受阿司匹林治疗的25名女性中有11名（44%）分娩出存活婴儿，接受肝素联合阿司匹林治疗的25名女性中有20名（80%）分娩出存活婴儿（p<0.05）。低剂量阿司匹林组与肝素联合低剂量阿司匹林组在分娩孕周（37.8±2.1 vs 37.2±3.4周）、剖宫产次数（18% vs 20%）或并发症方面无显著差异。
对于抗磷脂抗体相关的复发性流产，肝素联合低剂量阿司匹林比单独使用低剂量阿司匹林能提供显著更好的妊娠结局。
