Montazeri A, McEwen J, Gillis C R
Department of Public Health, University of Glasgow, UK.
Support Care Cancer. 1996 May;4(3):169-79. doi: 10.1007/BF01682336.
Ovarian cancer is the most malignant cancer in women, where it is the fifth leading cause of cancer-related death. The disease and its treatment have considerable effects on the quality of life of patients with this cancer. This study reviews existing literature on quality of life in patients with ovarian cancer to demonstrate the importance of the topic, to comment on improvements achieved and to consider their implications for the implementation of optimal treatment. A literature search was carried out through MEDLINE and of published papers on quality of life in patients with ovarian cancer from 1976 to 1994. Twenty papers have been reviewed, of which, 10 were treatment-related assessments of quality of life and the remaining 10 dealt with different topics including psychometric issues in measuring health-related quality of life. Twenty-four instruments were employed to measure quality of life. Of these, the Rotterdam Symptom Checklist (RSCL) and The European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) were found to be the most appropriate. Although meta-analysis of results is impossible, it appears that debulking surgery followed by platinum-based chemotherapy could improve both quality of life and survival. In addition to effective and efficient treatment, psychological counselling, palliative and home care, nutritional support and pain relief are the most important areas for improving quality of life of patients with ovarian cancer. Knowledge and insight into the quality of life of patients with ovarian cancer are still limited, and a large carefully planned international study is required. Use of existing standard measures is preferable and agreement should be reached on a selected single instrument.
卵巢癌是女性中最具恶性的癌症，是癌症相关死亡的第五大主要原因。该疾病及其治疗对患有这种癌症的患者的生活质量有相当大的影响。本研究回顾了关于卵巢癌患者生活质量的现有文献，以证明该主题的重要性，对已取得的改善进行评论，并考虑其对实施最佳治疗的影响。通过MEDLINE对1976年至1994年发表的关于卵巢癌患者生活质量的论文进行了文献检索。共审查了20篇论文，其中10篇是与治疗相关的生活质量评估，其余10篇涉及不同主题，包括测量健康相关生活质量中的心理测量问题。使用了24种工具来测量生活质量。其中，鹿特丹症状清单（RSCL）和欧洲癌症研究与治疗组织核心生活质量问卷（EORTC QLQ-C30）被认为是最合适的。尽管无法对结果进行荟萃分析，但似乎减瘤手术继以铂类化疗可以改善生活质量和生存率。除了有效和高效的治疗外，心理咨询、姑息治疗和家庭护理、营养支持和疼痛缓解是改善卵巢癌患者生活质量的最重要领域。对卵巢癌患者生活质量的认识和见解仍然有限，需要进行一项精心策划的大型国际研究。使用现有的标准措施更为可取，并且应该就选定的单一工具达成共识。
