Golay J, Basilico L, Loffarelli L, Songia S, Broccoli V, Introna M
Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche, Mario Negri, Milan, Italy.
Int J Clin Lab Res. 1996;26(1):24-32. doi: 10.1007/BF02644770.
The myb family of genes include the virally encoded v-myb oncogene, its normal cellular equivalent c-myb and two related members called A-myb and B-myb. They are all transcription factors that recognize the same DNA sequence (PyAACG/TG) and are all involved in the regulation of proliferation and differentiation in different cell types, including hematopoietic cells. C-myb is most highly expressed in hematopoietic cells and its oncogenic activation leads to transformation of these cells. Several lines of evidence have demonstrated that c-myb regulates both the proliferation and differentiation of hematopoietic cells of different lineages. The mechanisms of action of c-myb and v-myb are becoming clearer, mostly through the study of the different genes that are regulated by these transcription factors and the cofactors with which c-myb and v-myb co-operate. More recently the biological and biochemical functions of the B-myb and A-myb gene products have been investigated. Evidence for the function of the different members of the myb family in relation to hematopoietic proliferation and differentiation is presented, and the different roles of the myb genes are discussed.
myb基因家族包括病毒编码的v-myb癌基因、其正常的细胞等同物c-myb以及另外两个相关成员A-myb和B-myb。它们都是识别相同DNA序列（PyAACG/TG）的转录因子，并且都参与不同细胞类型（包括造血细胞）的增殖和分化调控。c-myb在造血细胞中表达水平最高，其致癌激活会导致这些细胞发生转化。多条证据表明，c-myb可调节不同谱系造血细胞的增殖和分化。c-myb和v-myb的作用机制正变得越来越清晰，这主要是通过对受这些转录因子调控的不同基因以及与c-myb和v-myb协同作用的辅因子进行研究实现的。最近，人们对B-myb和A-myb基因产物的生物学和生化功能进行了研究。本文介绍了myb家族不同成员在造血增殖和分化方面的功能证据，并讨论了myb基因的不同作用。
