Nakao A, Harada A, Nonami T, Kaneko T, Takagi H
Department of Surgery II, Nagoya University School of Medicine, Japan.
Pancreas. 1996 May;12(4):357-61. doi: 10.1097/00006676-199605000-00006.
To elucidate the clinical significance of neural invasion in pancreatic carcinoma, a clinicopathological study was performed. Neural invasion is a common feature of pancreatic carcinoma whose clinical significance has not yet been determined. Over a period of > 10 years, 129 of 204 (63%) patients with pancreatic carcinoma underwent resection by extensive radical surgery. A clinicopathological study of those specimens of pancreatic carcinoma was performed, with particular reference to neural invasion. Intrapancreatic neural invasion was observed in 116 of 129 (90%), of which 80 (69%) showed extrapancreatic nerve plexus involvement. A statistically significant (p < 0.001) correlation between the grade of intrapancreatic neural invasion and extrapancreatic nerve plexus invasion was observed. The postoperative survival rate for patients with extrapancreatic nerve plexus involvement was significantly (p < 0.001) lower than that for patients without extrapancreatic nerve plexus involvement. Patients who survived for > 3 years after operation had no extrapancreatic nerve plexus invasion even when portal vein wall invasion was observed.
为阐明神经侵犯在胰腺癌中的临床意义，进行了一项临床病理研究。神经侵犯是胰腺癌的一个常见特征，其临床意义尚未确定。在超过10年的时间里，204例胰腺癌患者中有129例（63%）接受了广泛根治性手术切除。对那些胰腺癌标本进行了临床病理研究，特别关注神经侵犯情况。129例中有116例（90%）观察到胰内神经侵犯，其中80例（69%）显示胰外神经丛受累。观察到胰内神经侵犯程度与胰外神经丛侵犯之间存在统计学显著相关性（p < 0.001）。胰外神经丛受累患者的术后生存率显著低于（p < 0.001）无胰外神经丛受累的患者。术后存活超过3年的患者即使观察到门静脉壁侵犯也无胰外神经丛侵犯。
