Kayahara M, Nagakawa T, Konishi I, Ueno K, Ohta T, Miyazaki I
Department of Surgery II, School of Medicine, Kanazawa University, Japan.
Int J Pancreatol. 1991 Oct;10(2):105-11. doi: 10.1007/BF02924113.
A clinicopathological study of 44 ductal carcinomas of the head of the pancreas revealed 39 with retroperitoneal invasion, of which 27 showed extrapancreatic plexus involvements. The second portion of the plexus pancreaticus capitalis was the most frequent site of invasion. A statistically significant correlation was found between neural invasion in the pancreatic tissue and plexus invasion, but no clear correlation was found between plexus invasion and lymphatic invasion or tumor size. Even small-sized tumors (t1) showed plexus invasion. The cases with plexus invasion had a statistically higher incidence of lymph-node involvement around the superior mesenteric artery than those without plexus invasion. These results indicate that complete dissection of extrapancreatic plexus around the superior mesenteric artery, including lymph nodes and soft tissue, could prolong the survival of patients with ductal carcinoma of the pancreas, even in cases of small-sized carcinomas.
一项对44例胰腺头部导管癌的临床病理研究显示，39例有腹膜后侵犯，其中27例显示胰外神经丛受累。胰头神经丛的第二部分是最常见的侵犯部位。在胰腺组织中的神经侵犯与神经丛侵犯之间发现了具有统计学意义的相关性，但在神经丛侵犯与淋巴侵犯或肿瘤大小之间未发现明显相关性。即使是小尺寸肿瘤（t1）也显示有神经丛侵犯。有神经丛侵犯的病例，肠系膜上动脉周围淋巴结受累的发生率在统计学上高于无神经丛侵犯的病例。这些结果表明，彻底切除肠系膜上动脉周围的胰外神经丛，包括淋巴结和软组织，即使在小尺寸癌的病例中，也可能延长胰腺导管癌患者的生存期。
