Bart P A, Jacquier P, Zuber P L, Lavanchy D, Frei P C
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Liver. 1996 Apr;16(2):110-6. doi: 10.1111/j.1600-0676.1996.tb00714.x.
Serum samples from 9006 women, who delivered in Switzerland in 1990 and 1991, were collected around the country. Of these women, 62.7% were Swiss and 37.3% originated from foreign countries. Samples were first screened for anti-HBc and those found positive were further tested for HBsAg, anti-HBs and anti-HDV. Anti-HBc was found in 640 of the 9006 women (overall prevalence, 7.1%; Swiss, 3.3%; foreigners, 13.5%). Of these 640 positive samples, 61 (9.5%) were positive for HBsAg (without anti-HBs), 467 (73.0%) positive for anti-HBs (without HBsAg) and 8 (1.3%) positive for both HBsAg and anti-HBs. The remaining 104 were thus anti-HBc positive without HBsAg or anti-HBs. These 104 specimens with the so-called "isolated anti-HBc" reactivity represented 1.2% of the whole population or 16.3% of the 640 anti-HBc positive mothers. All were HBV DNA negative (PCR). Anti-HDV antibody was found in only five women. HBsAg was seen in 38 of the cord-blood samples from the anti-HBc positive mothers. In this large sampling, we observed a relatively high seroprevalence of HBV infection. Cases with isolated anti-HBc reactivity, being HBV DNA negative by PCR, were probably non-infectious at the time of blood collection.
收集了1990年和1991年在瑞士分娩的9006名妇女的血清样本，样本采集遍布瑞士全国。这些妇女中，62.7%为瑞士人，37.3%来自外国。样本首先进行抗-HBc筛查，抗-HBc检测呈阳性的样本进一步检测HBsAg、抗-HBs和抗-HDV。9006名妇女中有640人抗-HBc呈阳性（总体患病率为7.1%；瑞士人3.3%；外国人13.5%）。在这640份阳性样本中，61份（9.5%）HBsAg呈阳性（无抗-HBs），467份（73.0%）抗-HBs呈阳性（无HBsAg），8份（1.3%）HBsAg和抗-HBs均呈阳性。因此，其余104份样本抗-HBc呈阳性，但无HBsAg或抗-HBs。这104份具有所谓“孤立性抗-HBc”反应性的样本占总体的1.2%，占640名抗-HBc阳性母亲的16.3%。所有样本HBV DNA均为阴性（PCR检测）。仅在5名妇女中发现抗-HDV抗体。抗-HBc阳性母亲的脐带血样本中有38份检测到HBsAg。在这个大规模样本中，我们观察到HBV感染血清阳性率相对较高。PCR检测显示HBV DNA阴性、具有孤立性抗-HBc反应性的病例在采血时可能无传染性。
