Richardson C T, Walsh J H, Cooper K A, Feldman M, Fordtran J S
J Clin Invest. 1977 Aug;60(2):435-41. doi: 10.1172/JCI108793.
These experiments were performed to determine the importance of cephalic-vagal stimulation in the acid secretory response to eating in normal human subjects. Cephalic stimulation was induced by a modified sham feeding (MSF) technique, during which subjects chewed and expectorated appetizing food. The response to MSF was compared with that to gastric distention with 600 ml NaCl, glucose, or food. In addition, we measured the extent to which cephalic stimulation augments acid secretion that has been stimulated simultaneously by these other mechanisms. Our conclusions are as follows: (a) cephalic stimulation accounts for approximately one-third of the acid secreted when all mechanisms act simultaneously (food-distention plus MSF); (b) within the limits imposed by the maximal secretory capacity, the response to MSF is approximately the same, regardless of whether acid secretion is otherwise unstimulated or is stimulated simultaneously by gastric distention with NaCl, glucose, or food; and (c) gastric distention prolongs the response to cephalic stimulation.
进行这些实验是为了确定在正常人类受试者中，头迷走神经刺激在进食引起的胃酸分泌反应中的重要性。通过改良假饲（MSF）技术诱导头刺激，在此期间受试者咀嚼并咳出开胃食物。将对MSF的反应与用600毫升氯化钠、葡萄糖或食物进行胃扩张的反应进行比较。此外，我们测量了头刺激增强由这些其他机制同时刺激的胃酸分泌的程度。我们的结论如下：（a）当所有机制同时起作用（食物扩张加MSF）时，头刺激约占分泌胃酸的三分之一；（b）在最大分泌能力所限定的范围内，无论胃酸分泌是否未受其他刺激，或者是否同时受到用氯化钠、葡萄糖或食物进行胃扩张的刺激，对MSF的反应大致相同；（c）胃扩张延长了对头刺激的反应。
