Moore J G, Motoki D
Gastroenterology. 1979 Jan;76(1):71-5.
It is believed that humans anticipate appetizing meals by increasing vagally mediated gastric acid secretion. Studies were conducted on 5 normal male volunteers to characterize further the secretory response to anticipated meals. Plasma gastrin and glucose levels were monitored to assess the possibility that these humoral factors participated in the observed secretory changes. Subjects were not fed for 22 hr and were intubated at 10 AM. Basal gastric collections were begun, and at 1 PM on different days, subjects either (a) selected meals of choice prepared in their presence for 1 hr before nasogastric tube withdrawal and meal ingestion or (b) were not food-teased or fed. Gastric collections were obtained every 10 min during the "test" hour (1-2 PM) during both (a) and (b) studies and titrated for gastric acid. Blood samples for plasma glucose and RIA gastrin were obtained during basal and test hours every 10 min. Pentagastrin-stimulated maximal acid output studies were conducted on all subjects on separate days. Results showed a progressive and statistically significant rise in gastric acid secretion when an appetizing, self-selected meal was anticipated. The magnitude of this rise was 55% of the mean pentagastrin-induced acid response. This acid response did not correlate with changes in plasma glucose or gastrin. The study demonstrated that pure psychic stimulation may be as effective an acid stimulant as sham feeding.
据信，人类通过增加迷走神经介导的胃酸分泌来预期美味的食物。对5名正常男性志愿者进行了研究，以进一步描述对预期食物的分泌反应特征。监测血浆胃泌素和葡萄糖水平，以评估这些体液因子参与观察到的分泌变化的可能性。受试者禁食22小时，并于上午10点插入胃管。开始收集基础胃液，在不同日期的下午1点，受试者要么（a）在拔鼻胃管和进食前1小时选择在其面前准备好的自选食物，要么（b）不进行食物逗引或喂食。在（a）和（b）研究的“测试”小时（下午1点至2点）期间，每10分钟收集一次胃液，并对胃酸进行滴定。在基础和测试小时期间，每10分钟采集一次用于检测血浆葡萄糖和放射免疫分析胃泌素的血样。在不同日期对所有受试者进行五肽胃泌素刺激的最大酸分泌量研究。结果显示，当预期有一顿美味的自选餐时，胃酸分泌呈渐进性且具有统计学意义的增加。这种增加的幅度是五肽胃泌素诱导的平均酸反应的55%。这种酸反应与血浆葡萄糖或胃泌素的变化无关。该研究表明，单纯的精神刺激可能与假饲一样是一种有效的酸刺激剂。
