Helman C A
Division of Gastroenterology, University of Alabama, Birmingham.
Am J Gastroenterol. 1988 Jun;83(6):640-2.
Modified sham feeding-stimulated gastric secretion is a recognized means of testing vagal integrity. The chew-and-spit technique is esthetically distasteful and difficult to perform without some of the food being swallowed. Simple chewing of an inert substance does not stimulate acid secretion. We thus tested to determine whether chewing gum, a potent cholinergic stimulant of salivary secretion, also stimulates the stomach. We compared the gastric acid output stimulated by the chew-and-spit method, using a cheeseburger chewed for 15 min, with gastric acid output stimulated by chewing seven sticks of chewing gum over 15 min, in 12 patients with duodenal ulcer disease. Acid output stimulated by chewing gum was 36% +/- 5%, and by cheeseburger was 39% +/- 6% of pentagastrin maximum acid output (r = 0.97). We conclude that chewing gum is a simple, cheap, convenient method for testing vagally mediated gastric acid secretion.
改良假饲刺激胃液分泌是一种公认的检测迷走神经完整性的方法。咀嚼并吐出食物的技术在美学上令人反感，而且如果不咽下一些食物就很难实施。单纯咀嚼惰性物质不会刺激胃酸分泌。因此，我们进行了测试，以确定口香糖（一种强力的唾液分泌胆碱能刺激剂）是否也会刺激胃部。我们比较了12例十二指肠溃疡患者在15分钟内咀嚼一个芝士汉堡后通过咀嚼并吐出法刺激的胃酸分泌量，与在15分钟内咀嚼七根口香糖刺激的胃酸分泌量。咀嚼口香糖刺激的胃酸分泌量为五肽胃泌素最大胃酸分泌量的36%±5%，咀嚼芝士汉堡刺激的胃酸分泌量为39%±6%（r = 0.97）。我们得出结论，咀嚼口香糖是一种简单、廉价、方便的检测迷走神经介导的胃酸分泌的方法。
