Wilson J E, Bynum L J, Ramanathan M
J Nucl Med. 1977 Jul;18(7):660-8.
A method for measuring regional distribution of ventilation and perfusion with Xe-133 during tidal breathing was developed with normal subjects, and compared with current breath-holding techniques in patients and in animals. Normal values for a ventilation index during washin, a perfusion index, and a washout slope index were determined in both supine and upright normal subjects. Comparisons of tidal-breathing and breath-holding measurements in patients with localized bullous disease of the lung showed roughly equal values for perfusion index by the two methods, but the tidal-breathing method was more sensitive to abnormalities in ventilation index. During occlusion of branches of the pulmonary artery in animals, the tidal-breathing and breath-holding methods were again comparable in the measurement of perfusion indices, but the tidal-breathing method provided a more sensitive assessment of ventilatory changes due to partial bronchial occlusion in animals. This technique appears superior to standard methods and is well suited to dynamic measurement of regional ventilation and perfusion in a number of experimental and clinical circumstances.
我们针对正常受试者开发了一种在潮气呼吸期间用Xe - 133测量通气和灌注区域分布的方法，并将其与目前用于患者和动物的屏气技术进行比较。在仰卧位和直立位的正常受试者中测定了吸入期间通气指数、灌注指数和洗脱斜率指数的正常值。对局限性肺大疱病患者的潮气呼吸和屏气测量结果进行比较，结果显示两种方法测得的灌注指数大致相等，但潮气呼吸法对通气指数异常更为敏感。在动物肺动脉分支闭塞期间，潮气呼吸法和屏气法在灌注指数测量方面再次具有可比性，但潮气呼吸法能更敏感地评估动物因部分支气管闭塞引起的通气变化。该技术似乎优于标准方法，非常适合在多种实验和临床情况下动态测量区域通气和灌注。
