van der Mark T W, Rookmaker A E, Kiers A, Peset R, Vaalburg W, Paans A M, Woldring M G
J Nucl Med. 1984 Nov;25(11):1175-82.
Due to the solubility of xenon-133 in blood and tissues, errors are introduced in the determination of regional pulmonary ventilation. We investigated these errors by comparing the results from ventilation measurements with Xe-133 and N-13 in five normal subjects (both at rest and during exercise) and in seven patients after a pneumonectomy. In the normal subjects at rest, the upper lung fields showed no significant difference in the uptake rates of the two gases. In the middle and lower lung fields, however, the uptake rate for Xe-133 was higher than for N-13. During exercise a significant increase of the specific ventilation was found in the upper lung fields for N-13 compared with Xe-133. In the pneumonectomy patients the overall uptake rate for Xe-133 in the intact hemithorax was 25% larger than for N-13. Over the pneumonectomized hemithorax the uptake of the fastest component of Xe-133 was (8.5 +/- 1.3)% of the total. The total chest-wall contribution of Xe-133 was (27 +/- 8)% of the total count rate.
由于氙 - 133在血液和组织中的溶解度，在区域肺通气测定中会引入误差。我们通过比较五名正常受试者（静息和运动时）以及七名肺叶切除术后患者使用Xe - 133和N - 13进行通气测量的结果来研究这些误差。在静息的正常受试者中，上肺野的两种气体摄取率无显著差异。然而，在中肺野和下肺野，Xe - 133的摄取率高于N - 13。运动时，与Xe - 133相比，上肺野中N - 13的比通气量显著增加。在肺叶切除术后患者中，完整半胸内Xe - 133的总体摄取率比N - 13大25%。在肺叶切除侧半胸，Xe - 133最快成分的摄取量占总量的(8.5 ± 1.3)%。Xe - 133在胸壁的总贡献占总计数率的(27 ± 8)%。
