Marabini R, Sirtori P, Chionna R, Barzizza L, Rubinacci A
Unità Metabolica dell'Osso, Istituto Scientifico H. San Raffaele, Italy.
J Endocrinol Invest. 1996 Mar;19(3):154-8. doi: 10.1007/BF03349858.
Aim of the study was to compare urinary galactosyl-hydroxylysine (GHyl), deoxypyridinoline (D-Pyr) and pyridinoline (Pyr) before and after 5 to 9 months of hormone replacement therapy (HRT) in postmenopausal women. The urinary markers were measured by HPLC in the second void of fasting samples and were expressed as ratio to creatinine. GHyl was also expressed as a ratio to glucosylgalactolysyl-hydroxylysine (GGHyl). After short-term hormone replacement therapy, urinary D-Pyr fell significantly, but Pyr and GHyl, also when expressed as a ratio to GGHyl, remained unmodified. We conclude that GHyl and Pyr are not useful markers in monitoring the bone response to HRT in postmenopausal women.
本研究的目的是比较绝经后妇女在激素替代疗法（HRT）5至9个月前后尿中的半乳糖基羟赖氨酸（GHyl）、脱氧吡啶啉（D-Pyr）和吡啶啉（Pyr）。通过高效液相色谱法（HPLC）测定空腹样本第二次排尿中的尿标志物，并以与肌酐的比值表示。GHyl也以与葡萄糖基半乳糖基羟赖氨酸（GGHyl）的比值表示。短期激素替代疗法后，尿D-Pyr显著下降，但Pyr和GHyl（即使以与GGHyl的比值表示）仍未改变。我们得出结论，GHyl和Pyr不是监测绝经后妇女对HRT的骨反应的有用标志物。
