Seyama Y, Hida A, Hayashi S, Buzzell G R
Department of Physiological Chemistry and Nutrition, University of Tokyo.
J Biochem. 1996 Apr;119(4):799-804. doi: 10.1093/oxfordjournals.jbchem.a021310.
Harderian glands of golden hamsters produce a copious lipid secretion, most of which is in the form of 1-alkyl-2,3-diacylglycerol (ADG). Sexual differences are seen in the composition of golden hamster ADG and in the morphology of secretory lipid droplet. ADGs from females contained abundant iso- and anteiso-branched chain alkyl groups and fatty acids [Seyama, Y., Otsuka, H., Ohashi, K., Vivien-Roels, B., and Pevet, P. (1995) J. Biochem. 117, 661-670]. Female hamsters were either untreated or given subcutaneous testosterone pellets. Treatment of females with testosterone led to the disappearance of such branched chain alkyl groups and fatty acids. Intact males had ADGs with entirely saturated straight chain alkyl groups and fatty acids. Castration led to the appearance of iso- and anteiso-branched chain alkyl groups and fatty acids. These observations suggested that the production of branched chain fatty acids in the Harderian gland of golden hamster is inhibited by testosterone at the step of isovaleryl-CoA dehydrogenase and 2-methyl branched-chain acyl-CoA dehydrogenase
金黄仓鼠的哈德氏腺会分泌大量脂质，其中大部分是以1-烷基-2,3-二酰基甘油（ADG）的形式存在。金黄仓鼠ADG的组成以及分泌性脂滴的形态存在性别差异。雌性的ADG含有丰富的异支链和反异支链烷基及脂肪酸[Seyama, Y., Otsuka, H., Ohashi, K., Vivien-Roels, B., and Pevet, P. (1995) J. Biochem. 117, 661 - 670]。雌性仓鼠要么不做处理，要么皮下植入睾酮丸剂。用睾酮处理雌性会导致此类支链烷基和脂肪酸消失。完整的雄性仓鼠的ADG含有完全饱和的直链烷基和脂肪酸。阉割会导致异支链和反异支链烷基及脂肪酸出现。这些观察结果表明，金黄仓鼠哈德氏腺中支链脂肪酸的产生在异戊酰辅酶A脱氢酶和2-甲基支链酰基辅酶A脱氢酶步骤受到睾酮抑制
