Rhee C Y, Spaet T H, Stemerman M B, Lajam F, Shiang H H, Caruso E, Litwak R S
J Lab Clin Med. 1977 Jul;90(1):77-84.
Since estrogen has been shown to reduce aortic medial hypertrophy in hypertensive rats, a naturally occurring estrogen compound, estradiol, was studied for its ability to suppress the intimal hyperplasia which follows vessel transection and anastomosis. Suture lines and adjacent abdominal aortas were examined by light and electron microscopy 1 month after surgery, in 23 rabbits. Test animals were given 200 microgram of Depoestradiol I.M. weekly, starting 3 days preoperatively. Control animals were similarly manipulated but received no estrogen. Control animals showed striking intimal thickening over the sutures, in contrast to the estrogen-treated group in which there was significantly less growth of corresponding tissue (p less than 0.01).
由于雌激素已被证明可减少高血压大鼠的主动脉中层肥厚，因此对一种天然存在的雌激素化合物雌二醇进行了研究，以探讨其抑制血管横断和吻合后内膜增生的能力。在23只兔子术后1个月，通过光镜和电镜检查缝合线及相邻腹主动脉。试验动物在术前3天开始每周肌肉注射200微克长效雌二醇。对照动物接受同样的操作，但未给予雌激素。与雌激素治疗组相比，对照动物在缝合处出现明显的内膜增厚，而雌激素治疗组相应组织的生长明显较少（p<0.01）。
